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. 2013 Oct 10;14:694. doi: 10.1186/1471-2164-14-694

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Copyright © 2013 Lamont et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MAP utilizes the β-oxidation pathway under all culture conditions. MAP inside MAC-T cells (co-cultured and alone) and macrophages (cultured alone) upregulated genes involved in the β-oxidation pathway. Upregulated genes involved in β-oxidation were fadD, fadE, enoyl-hydratases, and a transcriptional regulator (MAP2591). Genes highlighted in dark blue were upregulated under single cell culture; underlined = macrophage, normal text = MAC-T. Genes highlighted in green were upregulated in MAC-T cells under co-cultured conditions.