Figure 2. Effects of the adipokines resistin, visfatin, leptin, and adiponectin on androstenedione production in vitro in the presence of LH: compared to control cells, adiponectin treatment (3μg/mL) decreased levels of androstenedione in medium (****p= <0.0001) when bovine theca cells were treated with LH and insulin (both at 100 ng/mL).

Small stimulatory effects of leptin and visfatin were also observed. The concentrations of adipokines were chosen on the basis of the relative serum levels in normal women. Data shown are mean+SD.