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. 2013 Nov 18;8(11):e81669. doi: 10.1371/journal.pone.0081669

Figure 5. Enhanced susceptibility of mesothelioma cells treated with 4EASO to cytotoxic drugs.

Figure 5

Mesothelioma cell lines transfected with mmASO or 4EASO were treated with the indicated concentration of gemcitabine (GEM) or pemetrexed (PEM) and viable cells were counted. Elevated cell death was found for cells treated in combination with 4EASO and pemetrexed or gemcitabine compared to each treatment alone. Concurrent treatment of mesothelioma cells with 4EASO combined with pemetrexed or gemcitabine suppresses proliferation compared to treatment with mmASO combined with pemetrexed or gemcitabine. Columns, the mean of three independent determinations of cell number normalized to untreated cells, bars, s.d. Averages of combination treatment was compared to either agent alone by Student’s t-test. * denotes a p value <0.05. NS = not statistically significant.