Table 2. Calcium antagonist activities on mouse K+ (80 mM) depolarized ileum and distal colon.
|
Ileum
|
Distal Colon
|
|||||
|---|---|---|---|---|---|---|
| Activitya (M ± S.E.M.) | IC50b (μM) | 95% conf lim (x10-6) | Activityc (M ± S.E.M.) | IC50b (μM) | 95% conf lim (x10-6) | |
| CurcumaExtract | 73 ± 0.2 | 0.021 | 0.0092–0.035 | 79 ± 0.9 | 0.089 | 0.066–012 |
a Percent inhibition of calcium-induced contraction on K+-depolarized (80 mM) mouse ileum longitudinal smooth muscle (0.05 mg/ml). Curcuma extract (0.1 mg/ml) inhibits contraction by 100%. b Calculated from concentration-response curves (Probit analysis by Litchfield and Wilcoxon [43], with n = 6-7). When the maximum effect was < 50%, the IC50 values were not calculated. c Percent inhibition of calcium-induced contraction on K+-depolarized (80 mM) mouse distal colon (0.5 mg/ml). curcuma extract (1 mg/ml) inhibits contraction by 100%.