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. 2013 Nov 18;8(11):e80652. doi: 10.1371/journal.pone.0080652

Table 2. Comparison between patients with and without LRE.

Characteristics At the time of Kasai At 3 months after Kasai
LRE (N = 27) Non-LRE (N = 42) P LRE (N = 27) Non-LRE (N = 42) P
Age (weeks) 14.04±8.13 7.85±4.00 <0.001
METAVIR fibrosis, 3/4 4/6 4/4 0.004
LSM value (kPa) 21.7 (4.1–45.0) 6.7 (3.1–45.0) <0.001 34.8 (13.7–75.0) 13.1 (3.5–22.2) <0.001
AST (IU/L) 208.0±112.3 107.0±87.0 <0.001 245.4±184.6 127.4±80.4 0.001
ALT (IU/L) 183.0±99.9 89.9±71.1 <0.001 196.2±102.4 144.5±97.7 0.039
Albumin (g/dL) 3.84±0.55 3.78±0.35 0.599 3.03±0.62 3.78±0.61 <0.001
Total bilirubin (mg/dL) 10.44±3.19 8.00±2.48 0.001 9.50±5.34 1.78±1.85 <0.001
Direct bilirubin (mg/dL) 8.64±2.78 6.00±2.21 <0.001 8.12±4.70 1.38±1.55 <0.001
GGT (IU/L) 671.5±425.7 530.3±424.5 0.182 650.2±250.4 403.6±312.2 0.001
ALP (IU/L) 795.3±488.6 557.4±432.9 0.038 657.9±396.2 493.5±320.8 0.063
PT-INR 1.113±0.272 1.005±0.152 0.038 1.431±0.671 0.998±0.126 <0.001
Platelet count (109/L) 499.8±191.4 469.5±123.1 0.425 252.9±198.1 323.8±188.0 0.139

LRE, liver related events; LSM, liver stiffness measurement; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; PT-INR, prothrombin time-international normalized ratio.