Table 2. Comparison between patients with and without LRE.
Characteristics | At the time of Kasai | At 3 months after Kasai | ||||
LRE (N = 27) | Non-LRE (N = 42) | P | LRE (N = 27) | Non-LRE (N = 42) | P | |
Age (weeks) | 14.04±8.13 | 7.85±4.00 | <0.001 | |||
METAVIR fibrosis, 3/4 | 4/6 | 4/4 | 0.004 | |||
LSM value (kPa) | 21.7 (4.1–45.0) | 6.7 (3.1–45.0) | <0.001 | 34.8 (13.7–75.0) | 13.1 (3.5–22.2) | <0.001 |
AST (IU/L) | 208.0±112.3 | 107.0±87.0 | <0.001 | 245.4±184.6 | 127.4±80.4 | 0.001 |
ALT (IU/L) | 183.0±99.9 | 89.9±71.1 | <0.001 | 196.2±102.4 | 144.5±97.7 | 0.039 |
Albumin (g/dL) | 3.84±0.55 | 3.78±0.35 | 0.599 | 3.03±0.62 | 3.78±0.61 | <0.001 |
Total bilirubin (mg/dL) | 10.44±3.19 | 8.00±2.48 | 0.001 | 9.50±5.34 | 1.78±1.85 | <0.001 |
Direct bilirubin (mg/dL) | 8.64±2.78 | 6.00±2.21 | <0.001 | 8.12±4.70 | 1.38±1.55 | <0.001 |
GGT (IU/L) | 671.5±425.7 | 530.3±424.5 | 0.182 | 650.2±250.4 | 403.6±312.2 | 0.001 |
ALP (IU/L) | 795.3±488.6 | 557.4±432.9 | 0.038 | 657.9±396.2 | 493.5±320.8 | 0.063 |
PT-INR | 1.113±0.272 | 1.005±0.152 | 0.038 | 1.431±0.671 | 0.998±0.126 | <0.001 |
Platelet count (109/L) | 499.8±191.4 | 469.5±123.1 | 0.425 | 252.9±198.1 | 323.8±188.0 | 0.139 |
LRE, liver related events; LSM, liver stiffness measurement; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; PT-INR, prothrombin time-international normalized ratio.