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. 2013 Nov 18;8(11):e79345. doi: 10.1371/journal.pone.0079345

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© 2013 Maarleveld et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Hundred stochastic simulations until t = 60.000 min ( time steps) were done with min⁻¹, min⁻¹, min⁻¹, and min⁻¹. (A) Accuracy of mean and standard deviation estimates as function of the number of fixed intervals. (B) Simulation time with fixed-interval output increases with the number of fixed intervals. Fixed-interval simulations were done with the StochPy interface to StochKit2 and include the time to calculate the associated probability distributions. (C) The stationary mRNA distribution for fixed intervals (red error bars, 1.96 ) vs. explicit output (blue 95% confidence interval). Note that 1.96 corresponds to a 95% confidence interval. (D) The stationary mRNA distribution for fixed intervals (red error bars, 1.96 ) vs. explicit output (blue 95% confidence interval).

Inline graphic — Hundred stochastic simulations until t = 60.000 min ( time steps) were done with min⁻¹, min⁻¹, min⁻¹, and min⁻¹. (A) Accuracy of mean and standard deviation estimates as function of the number of fixed intervals. (B) Simulation time with fixed-interval output increases with the number of fixed intervals. Fixed-interval simulations were done with the StochPy interface to StochKit2 and include the time to calculate the associated probability distributions. (C) The stationary mRNA distribution for fixed intervals (red error bars, 1.96 ) vs. explicit output (blue 95% confidence interval). Note that 1.96 corresponds to a 95% confidence interval. (D) The stationary mRNA distribution for fixed intervals (red error bars, 1.96 ) vs. explicit output (blue 95% confidence interval).