Table 1. The participants’ clinical characteristics based on lung disease status.
MAC-LD n=56 | MAC contamination n=11 | M. kansasii-LD n=14 | RGM-LD** n=26 | PTB n=48 | TB contacts n=42 | |
---|---|---|---|---|---|---|
Age (years) | 67.8 [16.0] | 60.9 [18.5] | 56.9 [17.4]* | 67.0 [13.3] | 60.9 [17.9]* | 50.1 [18.5]* |
Male gender | 28 (50%) | 7 (64%) | 11 (79%) | 16 (62%) | 32 (67%) | 13 (31%) |
Disease duration (months) | 13.2 [21.8] | - | 2.9 [8.2]* | 4.3 [7.5]* | 1.3 [1.1]* | - |
Underlying co-morbidity | 18 (32%) | 4 (36%) | 3 (21%) | 9 (35%) | 23 (48%) | 5 (12%)* |
Diabetes mellitus | 4 (7%) | 1 (9%) | 1 (7%) | 3 (12%) | 7 (15%) | 3 (7%) |
Malignancy*** | 7 (13%) | 1 (9%) | 1 (7%) | 2 (8%) | 9 (19%) | 2 (5%) |
Hemodialysis | 0 | 1 (9%)* | 0 | 2 (8%)* | 3 (6%) | 0 |
Autoimmune diseases**** | 5 (9%) | 0 | 1 (7%) | 0 | 2 (4%) | 0* |
Liver cirrhosis | 2 (4%) | 1 (9%) | 0 | 2 (8%) | 8 (17%)* | 0 |
Past TB history | 8 (14%) | 2 (18%) | 4 (29%) | 1 (4%) | 0* | 0* |
MAC GPL antibody, U/mL | 4.27 [6.32] | 0.45 [0.73]* | 0.16 [0.15]* | 1.11 [2.27]* | 0.78 [2.47]* | 0.28 [0.74]* |
Leukocytes, per µL | 6926 [2743] | 7045 [2225] | 9063 [5082] | 7528 [3628] | 7661 [3658] | - |
Hemoglobin, g/dL | 12.6 [2.1] | 12.6 [2.5] | 12.2 [2.3] | 12.2 [2.2] | 12.7 [2.0] | - |
Abbreviations: GPL, glycopeptidolipid; LD, lung disease; MAC, Mycobacterium avium complex; NTM, non-tuberculous mycobacteria; PTB, pulmonary tuberculosis; RGM, rapidly-growing mycobacteria
Data are no. (%) or mean [standard deviation]
p<0.05 between the indicated group and the MAC-LD group
RGM includes 14 M. abscessus, 7 M. fortuitum, and 5 M. chelonae
Malignancy includes 5 lung cancer, 4 head and neck cancer, 3 leukemia, 3 hepatoma, 2 breast cancer, 2 bladder cancer, 2 biliary tract cancer, and 1 thyroid cancer
Autoimmune diseases includes 3 rheumatoid arthritis, and each one of systemic lupus erythematosus, ankylosing spondilytis, Sjögren syndrome, Graves' disease, and autoimmune related nephrotic syndrome