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. 2013 Nov 18;8(11):e78617. doi: 10.1371/journal.pone.0078617

Figure 4. CFHR2 regulates AP complement activation.

Figure 4

(A) CFHR2 inhibits AP activation in NHS. (B) CFHR2 had no effect on CP activation in NHS. TCC deposition in untreated NHS was set as 100%. C4bp is a classical pathway inhibitor. (C) CFHR2 and CFHR2/1–2 but not CFHR2/3–4 inhibited C3b deposition. (D) C3a generation in NHS activated via AP (ELISA). C3b depositon in untreated NHS was set as 100%. (E) CFHR2 together with factor H increased inhibition of C3b deposition in NHS as compared to CFHR2 or factor H alone. Data in (A–E) represent the mean values ± SD of three independent experiments (*p≤0.05, ***p≤0.001). Control (ctrl) indicates binding of the detection Ab to the plate.