Table 1. Chromosome regions with nonparametric linkage Z score (NPL Z)>3.0.
Chromosomeregion | Peak SNP | Position (cM)a | Position (Mb) | NPL Z | LODb | Peak region (cM) | Peak region (Mb, hg18) |
5p13∼p14 | rs2034586 | 48.70 | 30.08 | 3.66 | −8.99 | 16.38−60.61 | 6.12−38.07 |
5q31 | rs1016344 | 136.60 | 134.60 | 3.66 | 3.01 | 135.86−152.10 (135.86−165.02)c | 133.44−148.71 (133.44−160.43)c |
10p15 | rs713588 | 17.89 | 5.93 | 3.58 | −9.27 | 4.44−32.09 | 1.96−13.10 |
12q22∼q23 | rs1030048 | 108.27 | 96.16 | 3.73 | −5.98 | 103.49−112.36 | 92.21−99.96 |
Genetic distance from the p-terminus according to the deCODE high-resolution map.
Scores obtained on simulation analyses yielding the maximum value on 5q31 (see text for detail).
The peak region of 5q31 in parenthesis means the interval corresponding to the region with LOD >3.0.