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. 2013 Nov 18;8(11):e78952. doi: 10.1371/journal.pone.0078952

Table 3. Association between living in a state not contributing to the annual ADAP budget and ART initiation and virologic suppression, U.S. NA-ACCORD, 2001–2009.

Outcome: 6-month ART initiation Outcome: 1-year virologic suppression
HR 95% CI HR 95% CI
Overall
No contribution (vs. any contribution)
Crude (N = 8,874) 0.56 0.49–0.63 0.75 0.67–0.83
Regression-adjusted (N = 8,874) 0.80 0.69–0.93 1.02 0.88–1.18
Propensity score-matched (N = 1,082) * 0.73 0.60–0.88 1.13 0.93–1.36
Dose-response effect (Ptrend) (N = 8,874) <0.001 0.25
No contribution 0.75 0.63–0.88 1.06 0.91–1.24
Contribution <20% 0.90 0.82–0.99 1.07 0.97–1.17
Contribution >20% 1.00 Ref. 1.00 Ref.
Injection drug users only (N = 1,824)
No contribution (vs. any contribution)
Crude 0.40 0.31–0.51 0.78 0.64–0.96
Regression-adjusted 0.67 0.47–0.95 1.14 0.82–1.59
Dose-response effect (Ptrend) 0.005 0.29
No contribution 0.58 0.40–0.86 1.21 0.83–1.74
Contribution <20% 0.81 0.63–1.04 1.10 0.85–1.42
Contribution >20% 1.00 Ref. 1.00 Ref.

ART = antiretroviral therapy, CI = confidence interval, HR = hazard ratio.

All analyses use Cox proportional hazards regression.

*

Hazard ratios obtained after 1∶3 matching (with replacement) 683 “exposed” to 399 “unexposed” individuals based on propensity of living in a state contributing to the ADAP budget.

Both regression-adjusted and propensity-score matched analyses account for the following variables: age; sex; race/ethnicity; transmission risk; CD4+ count and viral load at eligibility; history of alcohol abuse, substance abuse, and mental disorders; year of eligibility; type of cohort; clinic-specific mechanisms to help obtain ART; state-level population density, % population of black race, % population below poverty line, median household income, and per capita Medicaid spending on HIV.