Table 3. Association between living in a state not contributing to the annual ADAP budget and ART initiation and virologic suppression, U.S. NA-ACCORD, 2001–2009.
Outcome: 6-month ART initiation | Outcome: 1-year virologic suppression | |||
HR | 95% CI | HR | 95% CI | |
Overall | ||||
No contribution (vs. any contribution) | ||||
Crude (N = 8,874) | 0.56 | 0.49–0.63 | 0.75 | 0.67–0.83 |
Regression-adjusted (N = 8,874) | 0.80 | 0.69–0.93 | 1.02 | 0.88–1.18 |
Propensity score-matched (N = 1,082) * | 0.73 | 0.60–0.88 | 1.13 | 0.93–1.36 |
Dose-response effect (Ptrend) (N = 8,874) | <0.001 | 0.25 | ||
No contribution | 0.75 | 0.63–0.88 | 1.06 | 0.91–1.24 |
Contribution <20% | 0.90 | 0.82–0.99 | 1.07 | 0.97–1.17 |
Contribution >20% | 1.00 | Ref. | 1.00 | Ref. |
Injection drug users only (N = 1,824) | ||||
No contribution (vs. any contribution) | ||||
Crude | 0.40 | 0.31–0.51 | 0.78 | 0.64–0.96 |
Regression-adjusted | 0.67 | 0.47–0.95 | 1.14 | 0.82–1.59 |
Dose-response effect (Ptrend) | 0.005 | 0.29 | ||
No contribution | 0.58 | 0.40–0.86 | 1.21 | 0.83–1.74 |
Contribution <20% | 0.81 | 0.63–1.04 | 1.10 | 0.85–1.42 |
Contribution >20% | 1.00 | Ref. | 1.00 | Ref. |
ART = antiretroviral therapy, CI = confidence interval, HR = hazard ratio.
All analyses use Cox proportional hazards regression.
Hazard ratios obtained after 1∶3 matching (with replacement) 683 “exposed” to 399 “unexposed” individuals based on propensity of living in a state contributing to the ADAP budget.
Both regression-adjusted and propensity-score matched analyses account for the following variables: age; sex; race/ethnicity; transmission risk; CD4+ count and viral load at eligibility; history of alcohol abuse, substance abuse, and mental disorders; year of eligibility; type of cohort; clinic-specific mechanisms to help obtain ART; state-level population density, % population of black race, % population below poverty line, median household income, and per capita Medicaid spending on HIV.