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. 2013 Nov 18;8(11):e79465. doi: 10.1371/journal.pone.0079465

Figure 2. Females are more likely to develop a preference for cocaine.

Figure 2

A. The development of cocaine preferences in male (open circles) and female (filled circles) rats (n = 12 per sex). Significant increase in the proportion of cocaine preferring (CP) females between the second and last FR5 tests (* p<0.05). The proportion of CP females was greater than males ($ p<0.05). B. The stability of preferences in PP rats and CP rats (both before and after CP developed). Significant difference between PP and CP rats within same preference category (# p<0.05). Significant difference in preference category before and after CP developed (* p<0.05). Significant difference between the “preference for cocaine” and “preference for pellets” categories within a given group (∧ p<0.05). PP rats (n = 16) and CP rats (n = 8). C. Representative self-administration behavior in a pellet preferring (PP) rat over the 21 FR sessions, displaying the number of infusions (grey) and pellets (black) earned each day during the cocaine-only or pellet-only sessions (closed symbols) and the choice session (open symbols). D. Representative self-administration behavior in a CP rat (CP criteria met on day 11 in this case).