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X-Gal stained skin whole-mounts from E18.5 male Gli3xt/xt;Gli1lzki/+ embryos show retention of MR#1, #2 and #4 (A). Examination of skins at high power revealed that MR#1 does not protruded from the surface of the skin (B), whereas MR#2 and #4 clearly evaginate (C, D). Elevated Wnt signaling activity can be seen in mesenchymal cells of protruding MR#2 from Gli3xt/xt;Conductinlz/+ embryos at this stage (E).
