Table 2. Cross validation performance estimation on dataset S2.

	PWEN-TLM-I (Optimistic)			PWEN-TLM-II (Moderate)			PWEN-TLM-III (Pessimistic)
	SP	SE	MCC	SP	SE	MCC	SP	SE	MCC
Positive (interacting)	0.8413	0.7988	0.6926	0.5832	0.9560	0.5515	0.7811	0.7622	0.6175
Negative (non-interacting)	0.8085	0.8494	0.6966	0.8780	0.3167	0.4143	0.7678	0.7864	0.6204
[AUC;Acc;MCC]	[0.9005;82.41%;0.6393]			[0.7661;63.63%;0.4258]			[0.8518;77.43%;0.6188]