Table 3. Human orthologs of yeast genes required for toxaphene tolerance.
| Yeast gene | Human ortholog(s) | Human protein description |
|---|---|---|
| CDC73 | CDC73 | Tumor suppressor; involved in transcriptional/post-transcriptional pathways |
| DST1 | TCEA1 | Transcription elongation factor A (SII) |
| HXK2 | HK2 | Hexokinase 2 |
| IRA2 | NF1 | Neurofibromin 1, tumor suppressor |
| PDR5 | ABCG2 | ATP-binding cassette protein |
| RAD6 | UBE2A/UBE2B | Ubiquitin-conjugating enzyme E2A |
| RPB9 | POLR2I | DNA-directed RNA pol. II subunit RPB9 |
| RTF1 | RTF1 | Role in transcription-coupled histone modification |
| SAC3 | GANP | Synonym MCM3AP, minichromosome maintenance protein 3 |
| SPT4 | SUPT4H1 | Regulates mRNA processing and transcription elongation by RNA pol. II |
| STP1 | ZNFN1A4 | Zinc finger protein, subfamily 1A, 4 (Eos) |
| THO2 | THOC2 | Component of the THO subcomplex of the TREX complex |
| THP1 | PCID2 | PCI domain containing 2 |
| TKL1 | TKTL1/2, TKT | Transketolase |
| UBP3 | USP10 | Ubiquitin specific peptidase 10 |
Deletion of any of these yeast genes caused sensitivity to toxaphene (listed in alphabetical order).