Figure 15. Comparison between the binding modes of 8a-d.

(a) Superimposition of the position of residues at binding site of heparanase when it is bounds to inhibitors 8a-8d Inhibitor molecules are removed for clarity. (b) Superimposition of the inhibitors 8a (gold), 8b (grey), at binding site of heparanase shows that despite differences in conformation there is interaction with the amine group in both molecules; (c) Superimposition of the inhibitors 8c (grey) and 8d (gold) shows that due to differences in conformation, there is no interaction with the amine group in 8c molecules.