Table 1. The parameters used in each model.

	Description	Cylindrical Model	3D Model	Cross-Sectional Model
µ	Spring constant	30 N Cell diameter-1	30 N Cell diameter-1	45 N Cell diameter-1
η	Drag coefficient	1 N hours Cell diameter-1	1 N hours Cell diameter-1	1 N hours Cell diameter-1
s	Equilibrium spring rest length	1 Cell diameter	1 Cell diameter	1 Cell diameter
β	Basement membrane force parameter	--	--	12 N Cell diameter-1
κs	Spontaneous curvature for crypt base	--	--	0.3 Cell diameter-1
AT	Threshold area for cell division	--	--	0.5 Cell diameter2
A0	Equilibrium area of a cell	$\frac{\sqrt{3}}{2}$Cell diameter2	$\frac{\sqrt{3}}{2}$Cell diameter2	$\frac{\sqrt{3}}{2}$Cell diameter2
ΔT	Timestep	0.005 hours	0.005 hours	0.0042 hours
HT	Threshold height for cell sloughing	12 Cell diameter	12 Cell diameter	0.9 of total crypt length (variable)
WT	Wnt threshold that defines the proliferative compartment	0.65	0.65	0.65