Table 1. Modulation of the expression of a series of phase I metabolization enzymes in HepG2 and A549 cells exposed for 14[a]P from 0.2 to 5 µM.
HepG2 | A549 | |||||
B[a]P (µM) | CYP1A2 | CYP3A4 | EPH | CYP1A2 | CYP3A4 | EPH |
0.2 | 3.25±0.34 * | 1.61±0.15 | 0.86±0.10 | 2.41±1.34 | 1.21±0.10 | 0.68±0.34 |
2 | 3.77±0.63 * | 1.14±0.11 | 0.77±0.22 | 2.64±0.78 | 1.29±0.05 | 0.77±0.22 |
5 | 4.79±1.45 * | 2.18±0.82 | 1.05±0.04 | 2.23±0.85 | 2.75±0.48 * | 0.80±0.19 |
(Statistically significant (p<0.05) with respect to (*) DMSO control of the concerned cell line).