Table 2. Modulation of phase I metabolism enzymes in HepG2 and A549 cells following exposure to 0.2 µM B[a]P.
HepG2 | A549 | |||||
Exposure time (h) | CYP1A2 | CYP3A4 | EPH | CYP1A2 | CYP3A4 | EPH |
0.5 | 0.66±0.28 | 1.94±0.12 * | 0.82±0.23 | 2.41±1.34 | 2.10±0.86 | 0.67±0.28 |
1 | 1.52±0.93 | 0.96±0.55 | 0.60±0.41 | 1.16±0.58 | 1.18±0.39 | 0.35±0.12 |
2 | 1.70±0.30 * | 1.56±0.28 | 0.80±0.21 | 1.68±0.85 | 1.01±0.32 | 0.75±0.19 |
4 | 4.47±0.31 * | 1.59±0.17 | 0.80±0.11 | 1.40±0.67 | 1.06±0.37 | 0.71±0.21 |
6 | 7.39±0.73 * | 1.43±0.21 | 0.93±0.14 | 1.34±0.78 | 1.37±0.41 | 0.90±0.13 |
14 | 4.76±0.94 * | 1.42±0.22 | 0.91±0.09 | 0.67±0.46 | 1.38±0.51 | 0.72±0.22 |
24 | 4.88±0.49 * | 2.12±0.07 * | 0.80±0.14 | 1.61±0.85 | 1.98±0.89 | 0.75±0.31 |
: significantly different from DMSO control of concerned cell line (p<0.05).