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. 2013 Nov 8;8(11):e80842. doi: 10.1371/journal.pone.0080842

Figure 2. The hwp1 SCH1211 null strain retains virulence in wild type and Tgm2-/- mice.

Figure 2

(A) Wild type C57BL/6 (n=6) and Tgm2 knock-out (n=13) mice were infected with 3-3.5 x 105 SCH1211 yeasts and observed for signs of illness over an eight day period. C57BL/6 mice (n=11) infected with the wild type parental strain, SC5314, served as comparator. The survival kinetics among the groups of mice was indistinguishable (P>0.05). The median survival day for all groups was 6 days. (B) Histological analysis of kidneys from C57BL/6 (WT, left panel) or Tgm2 knock-out (Tgm2-/-, right panel) mice sacrificed 3-days post infection with SCH1211. Kidney sections were stained with period acid Schiff to visualize fungal elements. Arrows point to hyphae penetrating the tissue. Size bar=50 µm.