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. 2013 Nov 8;8(11):e80842. doi: 10.1371/journal.pone.0080842

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© 2013 Staab et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

BALB/c mice infected with hwp1Δ/Δ strains SCH1211 (n=11) or DD27-U1 (n=6) were attenuated in virulence in intravenously infected BALB/c mice. Reintroducing HWP1 at its native site in SCH1211 (HR615, n=7) did not restore full virulence of the strain to wild type levels (SC5314, n=13). The rate of survival among the strains deleted for HWP1 (SCH1211 and DD27-U1) or expressing a single allele (HR615) was statistically different (P<0.05) relative to the wild type SC5314.