Table 4. Other notable dasatinib-responsive phosphotyrosine sites identified in untreated HCT-116 xenograft tumors: comparison to dasatinib-treated animals.
Protein | Functional Class | Site | IDs (untreated, 4hr Das) |
---|---|---|---|
RAIG-1 | Other Signaling | Y347 | 15, 1 |
PKCδ | Protein Kinase: AGC | Y334 | 14, 0 |
SHC1 | Other Signaling | Y427 | 13, 0 |
α-enolase | Metabolic Enzyme | Y44 | 13, 3 |
SHIP2 | Other Signaling | Y986 | 11, 0 |
Abbreviations: PKCδ, Protein kinase C delta type; PRP4, Serine/threonine-protein kinase PRP4 homolog; RAIG-1, Retinoic acid-induced protein 3; SHC1, SHC-transforming protein 1; SHIP2, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2.