Fig. 3.

a–d MP2 gene loci display subtype-independent differential methylation pattern with tumors exhibiting lower methylation compared to normal tissue. SERPINB5 methylation in a UNC breast tumors and matched normal tissue and b TCGA breast tumors and matched normal tissue are displayed in scatterplots of individual CpG units in the UNC dataset, and by β values for matched SERPINB5 probe cg20837735. MP2 “SI-HyperN” gene loci display significantly lower average percent methylation in tumor samples vs. matched normal tissue in both the c UNC dataset and were recapitulated in d the TCGA dataset. T test p values for methylation differences between tumor vs. normal samples are provided in the top right of each box plot