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. 2013 Nov 19;3:285. doi: 10.3389/fonc.2013.00285

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Copyright © 2013 Pillozzi, Fortunato, De Lorenzo, Borrani, Giachi, Scarselli, Arcangeli and Noci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of LH-R over-expression and LH on distant metastases in the orthotopic xenograft model of endometrial cancer. (A,B) Hematoxylin and eosin (H&E) sections of lung metastases from mice orthotopically engrafted Hec1A and from mice orthotopically engrafted Hec1A-LH-R. Tumor cells (see arrows) are present in the lung parenchyma and inside vessels (40× magnification). (C) Morphometric analysis of tumor cells invasion in the lungs. Histograms represent the mean of the area of invasion ± SEM (error bars). Mann–Whitney test has been performed (p = 0.0043). Asterisk indicate statistical significance;p < 0.05.