Table 2.
Recurrence free survival (RFS) by patient characteristics
| Variable |
Level |
N |
Event |
Median RFS time in months (95% CI) |
RFS rate at 3 years (95% CI) |
RFS rate at 5 years (95% CI) |
P-value |
|---|---|---|---|---|---|---|---|
| All patients | 599 | 277 | 68.79 (61.4,81.8) | 0.65 (0.61,0.69) | 0.54 (0.5,0.59) | ||
| Age (years) |
< 66 |
277 |
107 |
81.7 (74.24,NA) |
0.69 (0.64,0.75) |
0.61 (0.55,0.67) |
0.008 |
| > = 66 |
322 |
170 |
56.67 (43.69,68.79) |
0.61 (0.56,0.67) |
0.49 (0.44,0.55) |
|
|
| BMI |
< =25 |
223 |
115 |
53.48 (37.42,NA) |
0.58 (0.51,0.65) |
0.46 (0.4,0.54) |
0.02 |
| >25 |
376 |
162 |
75.33 (67.05,NA) |
0.69 (0.65,0.74) |
0.59 (0.54,0.65) |
|
|
| Gender |
F |
281 |
114 |
87.52 (72.34,NA) |
0.71 (0.65,0.76) |
0.62 (0.56,0.68) |
0.0002 |
| M |
318 |
163 |
53.78 (41.85,68.66) |
0.6 (0.55,0.66) |
0.47 (0.42,0.54) |
|
|
| ASA |
2 |
63 |
23 |
NA (63.24,NA) |
0.7 (0.59,0.83) |
0.62 (0.5,0.76) |
0.04 |
| 3 |
500 |
230 |
69.97 (60.35,NA) |
0.65 (0.61,0.69) |
0.55 (0.5,0.59) |
|
|
| 4 |
35 |
24 |
39.13 (20.4,NA) |
0.56 (0.42,0.76) |
0.38 (0.25,0.59) |
|
|
| Stage |
1 |
332 |
121 |
87.19 (81.8,NA) |
0.75 (0.71,0.8) |
0.64 (0.59,0.7) |
< 0.0001 |
| 2 |
125 |
74 |
48.65 (27.73,66.52) |
0.55 (0.46,0.64) |
0.43 (0.35,0.53) |
|
|
| 3 |
140 |
82 |
31.44 (20.01,67.05) |
0.49 (0.41,0.58) |
0.4 (0.33,0.5) |
|
|
| Preoperative |
N |
497 |
222 |
74.24 (65.54,NA) |
0.67 (0.63,0.72) |
0.57 (0.52,0.61) |
0.001 |
| Hb < 12 g/dL |
Y |
101 |
55 |
39.13 (23.75,NA) |
0.52 (0.43,0.63) |
0.42 (0.33,0.54) |
|
| BT |
N |
548 |
244 |
74.24 (66.52,7.52) |
0.67 (0.63,0.71) |
0.57 (0.52,0.61) |
0.0002 |
| Y |
51 |
33 |
23.98 (16.98,55.22) |
0.4 (0.28,0.57) |
0.29 (0.18,0.45) |
|
|
| Number of units |
0 |
548 |
244 |
74.24 (66.52,87.52) |
0.67 (0.63 0.71) |
0.57 (0.52,0.61) |
0.001 |
| Transfused |
1-3 |
31 |
19 |
24.34 (10.32,NA) |
0.4 (0.25,0.63) |
0.32 (0.19,0.55) |
|
| 4-9 |
12 |
8 |
24.24 (22.21,NA) |
0.42 (0.2,0.88) |
0.21 (0.06,0.72) |
|
|
| >10 |
6 |
5 |
17.85 (3.45,NA) |
0.33 (0.11,1) |
0.17 (0.03,1) |
|
|
| Preoperative |
N |
501 |
217 |
77.63 (66.69,NA) |
0.69 (0.65,0.73) |
0.58 (0.53,0.62) |
< 0.0001 |
| Chemo-radiation |
Y |
98 |
60 |
21.71 (13.83,55.22) |
0.45 (0.36,0.56) |
0.38 (0.29,0.49) |
|
| Postoperative |
Chemo only |
132 |
57 |
81.8 (60.35,NA) |
0.67 (0.59,0.76) |
0.58 (0.5,0.68) |
< 0.0001 |
| Therapy | Chemo/Radiation |
54 |
35 |
34.92 (17.35,74.24) |
0.49 (0.36,0.65) |
0.39 (0.28,0.56) |
|
| None |
378 |
160 |
75.33 (66.52,NA) |
0.69 (0.65,0.74) |
0.58 (0.53,0.63) |
|
|
| Radiation only | 35 | 25 | 20.66 (3.47,51.35) | 0.38 (0.25,0.59) | 0.27 (0.15,0.46) |
P-values from the log-rank test (univariable analysis), p < 0.05 is considered statistically significant. BMI Body mass index. ASA American Society of Anesthesiologist physical status. Hb Hemoglobin.