Table 2.
Biodistribution*
| |
P6c/P6c-BN 50:10 |
P6c-PEG/P6c-BN 50:10 |
P6c-PbK-PEG/P6c-BN 50:10 |
P6c-PbK-PEG/P6c-BN 40:20 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Organ | 1 h | 4 h | 24 h | 1 h | 4 h | 24 h | 1 h | 4 h | 24 h | 1 h | 4 h | 24 h |
| Blood |
0.31(4) |
0.25(8) |
0.13(2) |
0.5(1) |
0.42(6) |
0.17(2) |
0.4(1) |
0.4(1) |
0.15(1) |
0.33(2) |
0.27(3) |
0.14(1) |
| Heart |
0.16(4) |
0.13(2) |
0.09(4) |
0.20(4) |
0.21(4) |
0.12(4) |
0.25(6) |
0.21(4) |
0.15(3) |
0.21(3) |
0.18(3) |
0.15(5) |
| Lung |
6(1) |
2.8(7) |
0.9(4) |
4.8(3) |
5(2) |
1.0(2) |
2.9(7) |
1.8(3) |
0.9(1) |
6(3) |
2.5(2) |
1.01(2) |
| Spleen |
37(10) |
31(7) |
19(4) |
43(11) |
27(6) |
18(4) |
21(3) |
22(5) |
9(1) |
32(6) |
33(8) |
20(4) |
| Kidneys |
2.5(2) |
3.8(9) |
4.5(1) |
3.8(3) |
7.4(9) |
7(1) |
3.0(8) |
4.4(8) |
3.5(3) |
3.3(3) |
4.3(1) |
5.1(4) |
| Pancreas |
0.4(6) |
0.3(1) |
0.05(5) |
2(2) |
0.23(1) |
0.3(1) |
0.17(5) |
0.4(3) |
0.3(2) |
1(1) |
1.1(9) |
0.12(7) |
| Stomach |
0.6(7) |
0.26(2) |
0.20(3) |
0.8(1) |
0.5(2) |
0.27(7) |
0.3(2) |
0.3(2) |
0.17(6) |
0.8(4) |
0.38(5) |
0.24(7) |
| Intestines |
0.23(4) |
0.22(4) |
0.21(6) |
0.33(5) |
0.26(2) |
0.20(5) |
0.4(2) |
0.44(3) |
0.25(5) |
0.6(2) |
0.34(6) |
0.3(1) |
| Colon |
0.25(9) |
0.22(5) |
0.3(1) |
0.3(1) |
0.30(7) |
0.22(5) |
0.25(6) |
0.4(2) |
0.15(4) |
0.3(1) |
0.26(3) |
0.21(2) |
| Liver |
78(7) |
68(4) |
40(11) |
67(6) |
66(5) |
49(12) |
103(34) |
85(13) |
38(3) |
77(9) |
73(17) |
49(2) |
| Muscle |
0.19(6) |
0.12(4) |
0.16(6) |
0.6(4) |
0.3(3) |
0.2(1) |
0.4(2) |
0.3(2) |
0.2(1) |
0.9(5) |
0.6(2) |
0.09(1) |
| Bone |
2.5(8) |
1.6(5) |
1.3(7) |
3(1) |
1.8(2) |
1.6(4) |
3(2) |
1.9(5) |
0.8(2) |
2(1) |
2.8(6) |
1.5(3) |
| Tu (av) |
0.12(2) |
0.13(4) |
0.13(6) |
0.2(1) |
0.2(1) |
0.2(1) |
0.16(6) |
0.18(7) |
0.09(4) |
0.2(1) |
0.13(2) |
0.11(4) |
| Bile |
6.6(7) |
3(2) |
9(7) |
12(12) |
8(7) |
4(2) |
8(3) |
12(4) |
15(10) |
10(10) |
12(8) |
13(11) |
| Urine | 19(10) | 30(24) | 21(2) | 39(8) | 57(9) | 14(2) | 23(20) | 111(10) | 17(2) | 27(4) | 30(5) | 9(5) |
*Data represent % injected dose per g tissue of four differently substituted SAPN at different time points after injection (the error of the last digit in parentheses).