Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Nov 18;210(12):2503–2513. doi: 10.1084/jem.20130168

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Enervald et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — 53BP1 foci formation is reduced at an early time point in NIPBL-deficient LCLs. LCLs from healthy controls or LCLs deficient in NIPBL (P1-P3, P5) were exposed to γ-IR (1Gy) and harvested, cytospun, and fixed at the indicated time points. The cells were then stained with anti-53BP1 antibodies and 53BP1 foci were detected using a confocal microscope. Image stacks were exported to ImageJ and 53BP1 foci were quantified in ∼40 nuclei per LCL per time point in each experiment. The bars represent the relative distribution of 53BP1 foci at indicated time points before and after γ-IR. Two independent experiments were performed. Statistically significant differences are highlighted with stars (Mann-Whitney U test).