Table 1.
DLK-interacting proteins identified by mass spectrometry
Gene | Uniprot Symbol | Present in PSD | Peptides in DLKlox:Creneg | Peptides in DLKlox:Crepos |
DLK | MAP3K12 | X | 23 | 1 |
Beta spectrin 2 | Spnb2 | X | 28 | 0 |
LZK | MAP3K13 | 13 | 0 | |
Neurofilament light | Nefl | X | 13 | 0 |
Neurofilament medium | Nefm | X | 12 | 0 |
Beta spectrin 3 | Spnb3 | X | 10 | 0 |
Internexin | Ina | X | 9 | 0 |
Matrin 3 | Matr3 | 7 | 0 | |
Purine rich binding protein element A | Pura | X | 7 | 0 |
Microtubule associate protein 1A | Map1a | X | 6 | 0 |
Contactin 1 | Cntn1 | X | 5 | 0 |
Actinin alpha 1 | Actn1 | X | 5 | 0 |
DEAH box polypeptide 9 | Dhx9 | 5 | 0 | |
Synaptic RAS GTPase activating protein | Syngap1 | X | 4 | 0 |
Microtubule associate protein 4 | Map4 | X | 4 | 0 |
Heterogeneous nuclear ribonucleoprotein a2b1 | HNRPa2b1 | 4 | 0 | |
BR serine/threonine kinase 1 | Brsk1 | 4 | 0 | |
PSD-95 | DLG4 | X | 3 | 0 |
Set binding factor 1 | sbf1 | X | 3 | 0 |
Kinesin family member 2A | Kif2 | X | 2 | 0 |
“Present in PSD” denotes peptides identified in PSD fraction after biochemical fractionation. All peptides except DLK and Map4 have been identified in multiple independent studies.