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. 2013 Nov 19;4:232. doi: 10.3389/fgene.2013.00232

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Copyright © 2013 Uemoto, Pong-Wong, Navarro, Vitart, Hayward, Wilson, Rudan, Campbell, Hastie, Wright and Haley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The power to achieve 5% genome-wide significance in the gene region. The powers in the simulation study for genome heritability 0.4 were calculated by RHM with window size 10 (RHM), single-SNP GWAS (GEMMA), and three gene-based association approaches (VEGAS, CCA, and SKAT) in the different situations. The number of QTL is on the x-axis, and the power to detect QTL is on the y-axis. Each graph shows the different situations for genome heritability 0.4 (QTL heritability is 0.05 or 0.025, and MAF is high or low).