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. 2013 Nov 19;4:232. doi: 10.3389/fgene.2013.00232

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Copyright © 2013 Uemoto, Pong-Wong, Navarro, Vitart, Hayward, Wilson, Rudan, Campbell, Hastie, Wright and Haley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparisons of regional heritability mapping (RHM) among different window sizes on a significant region for three eye traits. Comparisons shown on the results of higher −log₁₀(P-value) (>5.0) for axial length (AL), central corneal thickness (CCT), and spherical equivalent refraction (SER). (A) The results of AL on chromosome 10. The plot shows the −log₁₀(P-value) of 100-SNP-window number 161 for RHM with win100 (Window161_100SNPs) and win20 (Window161_20 SNPs), 100-SNP-window number 162 for RHM with win100 (Window162_100SNPs) and win20 (Window162_20SNPs), and 100-SNP-window numbers 161 and 162 for RHM with win10 (10SNPs). The red horizontal line is drawn at the 5% genome-wide significance for RHM with win10. (B) The result of CCT on chromosome 16. The plot shows the −log₁₀(P-value) of 100-SNP-window number 156 for RHM with win100 (Window156_100SNPs) and win20 (Window156_20 SNPs), 100-SNP-window number 157 for RHM with win100 (Window157_100SNPs) and win20 (Window157_20SNPs), and 100-SNP-window numbers 156 and 157 for RHM with win10 (10SNPs). The red horizontal line is drawn at the 5% genome-wide significance for RHM with win10. (C) The result of SER on chromosome 2. The plot shows the −log₁₀(P-value) of 100-SNP-window number 197 for RHM with win100 (Window197_100SNPs) and win20 (Window197_20 SNPs), 100-SNP-window number 198 for RHM with win100 (Window198_100SNPs) and win20 (Window198_20SNPs), and 100-SNP-window numbers 197 and 198 for RHM with win10 (10SNPs). The red horizontal line is drawn at the 5% genome-wide significance for RHM with win20. (D) The result of SER on chromosome 10. The plot shows the −log₁₀(P-value) of 100-SNP-window number 161 for RHM with win100 (Window161_100SNPs) and win20 (Window161_20 SNPs), 100-SNP-window number 162 for RHM with win100 (Window162_ 100SNPs) and win20 (Window162_20SNPs), and 100-SNP-window numbers 161 and 162 for RHM with win10 (10SNPs). The red horizontal line is drawn at the 5% genome-wide significance for RHM with win10.