Table 3.
Summary of the significant regions for Regional heritability mapping (RHM) and other methods in Axial Length, Central Corneal Thickness, and Spherical Equivalent Refraction.
| Trait1 | Chromosome | Window size | RHM | Other methods | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP number | SNP name and position | MAF | Heritability | P-value4 | |||||||||||||
| Start | End | Start | End | Min | Mean | Max | LRT2 | P-value3 | Regional | Genome | GEMMA5 | VEGAS | CCA | SKAT | |||
| AL | 10 | 10 | 8051 | 8060 | rs1877591 | rs11002552 | 0.08 | 0.14 | 0.28 | 21.2 | 4.2 × 10−6 | 0.049 | 0.438 | 4.7 × 10−3 | 6.9 × 10−3 | 1.4×10−2 | 6.2×10−2 |
| 79,784,171 | 79,870,936 | ||||||||||||||||
| CCT | 9 | 10 | 13,711 | 13,720 | rs1536482 | rs4304399 | 0.05 | 0.22 | 0.49 | 8.1 | 4.4 × 10−3 | 0.013 | 0.818 | 1.0 × 10−7** | 1.1 × 10−3 | 1.8 × 10−4 | 9.8 × 10−1 |
| 134,666,473 | 134,746,881 | ||||||||||||||||
| 16 | 20 | 7811 | 7830 | rs7403882 | rs8044502 | 0.08 | 0.27 | 0.52 | 23.6 | 1.2 × 10−6** | 0.026 | 0.799 | 3.3 × 10−11** | 1.0 × 10−6** | 4.2 × 10−5 | 1.8 × 10−1 | |
| 86,639,452 | 87,003,009 | ||||||||||||||||
| 16 | 10 | 7821 | 7830 | rs12597413 | rs8044502 | 0.16 | 0.34 | 0.52 | 27.0 | 2.1 × 10−7** | 0.026 | 0.795 | 3.3 × 10−11** | 0** | 3.0 × 10−6 | 7.5 × 10−1 | |
| 86,782,559 | 87,003,009 | ||||||||||||||||
| SER | 2 | 20 | 9871 | 9890 | rs4851411 | rs3923053 | 0.10 | 0.25 | 0.53 | 22.6 | 2.0 × 10−6** | 0.150 | 0.349 | 6.9 × 10−2 | 6.0 × 10−1 | 9.2 × 10−1 | 7.0 × 10−1 |
| 101,260,596 | 101,444,879 | ||||||||||||||||
| 2 | 10 | 9881 | 9890 | rs7568067 | rs3923053 | 0.10 | 0.21 | 0.48 | 21.1 | 4.4 × 10−6 | 0.112 | 0.369 | 6.9 × 10−2 | 5.1 × 10−1 | 5.5 × 10−1 | 8.1 × 10−1 | |
| 101,385,329 | 101,444,879 | ||||||||||||||||
| 10 | 10 | 8051 | 8060 | rs1877591 | rs11002552 | 0.08 | 0.14 | 0.28 | 28.9 | 7.5 × 10−8** | 0.092 | 0.362 | 2.9 × 10−2 | 7.2 × 10−3 | 2.0 × 10−1 | 1.4 × 10−1 | |
| 79,784,171 | 79,870,936 | ||||||||||||||||
1
AL, Axial Length; CCT, Central Corneal Thickness; SER, Spherical Equivalent Refraction.
2
Likelihood ratio test statistics.
3
For guidance, the 5% genome-wide significance for RHM with window size 10 (P-value = 1.8 × 10−6) and window size 20 (P-value = 3.7 × 10−6).
4
For guidance, the 5% genome-wide significance for GEMMA (P-value = 1.8 × 10−7), 5% genome-wide significance for gene-based association approaches with window size 10 (P-value = 9.2 × 10−7) and window size 20 (P-value = 1.8 × 10−6).
5
The minimum P-value in the window was selected.
6**
5% genome-wide significance level.