Table 2. High frequency ovarian cancer autoantibody targets.
High frequency autoantibody targets identified by top-down proteomics microarray screening and iTRAQ quantitative proteomics analysis. (A) Autoantibodies found in ovarian cancer as compared to benign ovarian disease and age matched healthy female samples. (B) Autoantibodies that were significantly higher in stage I cancer samples as compared to stage II-IV samples.
| 2A. OVCA Specific as compared to benign and normal | |||
|---|---|---|---|
| Protein Name | Symbol | Uniprot | P-Value |
| Cofilin-1 | CFL1 | P23528 | 0.095925132 |
| Ezrin | EZR | P15311 | 0.086806974 |
| HistoneH1.2 | HIST1H1C | P16403 | 0.034922637 |
| Heterogeneous nuclear ribonucleoprotein A/B | HNRNPAB | Q99729 | 0.079023531 |
| Stress-70 protein, mitochondrial | HSPA9 | P38646 | 0.00865349 |
| PDZ domain-containing protein 11 | PDZD11 | Q5EBL8 | 0.000796403 |
| Profilin-1 | PFN1 | P07737 | 0.000864174 |
| Peptidyl-prolyl cis-1rans isomer ase A | PPIA | P62937 | 0.000187017 |
| Small EDRK-rich factor 2 | SERF2 | P84101 | 0.043832054 |
| Tubulin alpha-1C chain | TUBA1C | Q9BQE3 | 0.001168379 |
| Junction plakoglobin | JUP | P14923 | 0.051950189 |
| 2B. OVCA stage I specific as compared to stage II-IV | |||
|---|---|---|---|
| Protein Name | Symbol | Uniprot | P-Value |
| Cofilin-1 | CFL1 | P23528 | 0.042964969 |
| Ezrin | EZR | P15311 | 0.040955999 |
| HistoneH1.2 | HIST1H1C | P16403 | 0.002287586 |
| Heat schock-related 70 kDa protein 2 | HSPA2 | P54652 | 0.000998804 |
| PDZ domain-containing protein 11 | PDZD11 | Q5EBL8 | 0.042129066 |
| Tubulin alpha-1C chain | TUBA1C | Q9BQE3 | 0.01001449 |
| Junction plakoglobin | JUP | P14923 | 0.067963873 |