Table 2.
Detection of Sequence Slippage
| Observed data (% slippage-like) | Simulated data (% slippage-like) | Significance (p) | ||
|---|---|---|---|---|
| All events | Deletions | 38.00% | 4.66% | <0.0001 |
| Insertions | 52.49% | 5.28% | <0.0001 | |
| Single-codon events | Deletions | 37.37% | 7.50% | <0.0001 |
| Insertions | 57.03% | 7.53% | <0.0001 | |
| Nonrepeat single codona | Deletions | 29.55% | 6.94% | <0.0001 |
| Insertions | 38.92% | 6.70% | <0.0001 |
Slippage-like is defined to be when a sequence adjacent to the indel is identical to the inserted or deleted sequence. For the simulated data, slippage status was averaged over all 1000 simulated data sets. P-values were calculated from two-tailed χ2 tests on raw counts.
a
The nonrepeating single-codon-event data sets have been purged of all events that were observed in the context of trinucleotide repeats of two or more adjacent trinucleotides (excluding the inserted or deleted sequence itself)