Table 1.
Numbers of Sequences Encoding Nuclear Receptors Found in Rat, Mouse, and Human Genomesa
| Sequence | Rat | Mouse | Human |
|---|---|---|---|
| NR genes | 47b | 49 | 48 |
| NR genes, aberrantc | 0 | 1 | 1 |
| NR pseudogenes | 3 | 4 | 3 |
| Domain singletonsd | |||
| DBD | 1 | 1 | 0 |
| LBD | 0 | 1 | 0 |
| SMDe | 0 | 0 | 1 |
a
Genome versions: human, April 2003; mouse, February 2003; rat, April 2003
b
All complete and partial genes are included in the tally (see text). Not tallied are NR1D2 and NR2E3, whose complete absence correlates with sequence gaps in the rat genome assembly at the location predicted by synteny with the mouse and human orthologs
c
One aberrant NR gene structure was identified in each of the human and the mouse genomes
d
Domain singletons not including DAX-1 and SHP, which are subfamily 0 NR genes
e
Steroid modulatory A/B domain. One GCR domain singleton was found in the human genome