Table 1.
Moxifloxacin Minimum Inhibitory Concentrations of Bacteria Isolates From Patients Using vs Not Using Topical Fluoroquinolones at Presentation
| S, I, or R |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Organism (No. [%]) | Fluoroquinolone Use at Presentation |
MIC, µg/mL |
% |
Threshold |
|||||||
| No. | MIC50 | MIC90a | S | I | R | S | R | Source | |||
| Streptococcus pneumoniae | No | 209 | 0.25 | 0.38 | 98 | 1 | 1 |  |
≤1 | ≥4 | Clinical and Laboratory Standards Institute,10 2012 |
| (247 [51.5]) | Yes | 38 | 0.25 | 0.38 | 97 | 0 | 3 | ||||
| Pseudomonas aeruginosa | No | 89 | 3 | 8 | 9 | 79 | 12 | |
≤1 | >4 | Andrews et al,11 2007 |
| (109 [22.7]) | Yes | 20 | 6 | 32 | 5 | 45 | 50 | ||||
| Nocardia species | No | 32 | 1.50 | 32 | 41 | 25 | 34 | |
≤1 | ≥4 | Andrews et al,12 1999 |
| (55 [11.5]) | Yes | 23 | 2 | 32 | 26 | 35 | 39 | ||||
| Staphylococcus coagulase | No | 19 | 0.25 | 4 | 58 | 11 | 32 | |
≤0.5 | >1 | Andrews et al,11 2007 |
| negative (21 [4.4]) | Yes | 2 | 0.11 | NA | 100 | 0 | 0 | ||||
| Moraxella species | No | 12 | 0.08 | 0.13 | 92 | 8 | 0 | |
<0.5 | >0.5 | Andrews et al,11 2007 |
| (13 [2.7]) | Yes | 1 | 5.97 | NA | 0 | 0 | 100 | ||||
| Staphylococcus aureus | No | 10 | 1.03 | 16 | 40 | 20 | 40 | |
≤0.5 | ≥2 | Clinical and Laboratory Standards Institute,10 2012 |
| (11 [2.3]) | Yes | 1 | 0.09 | NA | 100 | 0 | 0 | ||||
| Streptococcus viridans | No | 6 | 0.22 | NA | 83 | 0 | 17 | |
≤1 | ≥4 | Clinical and Laboratory Standards Institute,10 2012 |
| group (10 [2.1]) | Yes | 4 | 0.22 | NA | 100 | 0 | 0 | ||||
| Corynebacterium species | No | 4 | 0.22 | NA | NA | NA | NA | NA | NA | NA | |
| (4 [0.8]) | Yes | 0 | NA | NA | |||||||
| Klebsiella species (3 [0.6]) | No | 3 | 0.13 | NA | NA | NA | NA | NA | NA | NA | |
| Yes | 0 | NA | NA | ||||||||
| Pseudomonas species, | No | 3 | 2 | NA | NA | NA | NA | NA | NA | NA | |
| non–P aeruginosa (3 [0.6]) |
Yes | 0 | NA | NA | |||||||
| Enterobacter species (2 | No | 1 | 0.13 | NA | 100 | 0 | 0 | |
≤0.5 | >1 | Andrews et al,11 2007 |
| [0.4]) | Yes | 1 | 0.50 | NA | 100 | 0 | 0 | ||||
| Bacillus species (1 [0.2]) | No | 0 | NA | NA | NA | NA | NA | NA | NA | NA | |
| Yes | 1 | 19 | NA | ||||||||
| Mycobacterium species | No | 0 | NA | NA | NA | NA | NA | NA | NA | NA | |
| (1 [0.2]) | Yes | 1 | 32 | NA | |||||||
| Total (480 [100]) | No | 388 | 0.25 | 4 | 68 | 22 | 10 | NA | NA | NA | |
| Yes | 92 | 0.38 | 32 | 57 | 19 | 24 | |||||
Abbreviations: I, intermediate; MIC, minimum inhibitory concentration; NA, not applicable; R, resistant; S, susceptible.
a
The MIC90 requires at least 9 isolates.