Table 3.

Association of clinical outcomes with treatment resistant hypertension.

Clinical outcomes	African American						White
	Number of events		Event rates per 1000 person-years		Odds ratio (P value) for cases versus controls		Number of events		Event rates per 1000 person-years		Odds ratio (P value) for cases versus controls
	TRH cases (n = 929)	Controls (n = 719)	TRH cases	Controls	Unadjusted	Adjusted*	TRH cases (n = 1274)	Controls (n = 1635)	TRH cases	Controls	Unadjusted	Adjusted*
CHD (fatal CHD or nonfatal MI)	82	25	18.0	6.9	2.66 (<0.001)	3.44 (<0.001)	159	75	26.2	9.4	2.80 (<0.001)	2.40 (<0.001)
Stroke	43	22	9.3	6.1	1.55 (0.10)	1.15 (0.66)	64	27	10.3	3.4	3.04 (<0.001)	2.19 (0.003)
Heart failure	104	22	23.2	6.0	3.86 (<0.001)	2.69 (<0.001)	184	50	30.7	6.2	5.03 (<0.001)	3.98 (<0.001)
End-stage renal disease	28	0	6.0	0	23.1 (0.002)**	10.9 (0.03)**	20	4	3.2	0.5	6.33 (0.001)	3.89 (0.02)
All-cause death	103	51	20.7	13.5	1.48 (0.02)	1.66 (0.01)	127	88	19.1	10.6	1.69 (<0.001)	1.35 (0.06)
Combined CHD	142	50	32.5	13.9	2.36 (<0.001)	2.84 (<0.001)	307	175	54.6	22.6	2.44 (<0.001)	2.22 (<0.001)
Combined CVD	277	110	69.4	32.0	2.18 (<0.001)	2.11 (<0.001)	510	282	100.7	38.0	2.70 (<0.001)	2.42 (<0.001)

*Adjusted for age, sex, randomized treatment group, baseline values of BMI, HDL, eGFR, SBP, and DBP, smoking status, diabetes status and history of LVH; **added 1 event into each case and control group to force estimate.