Table 1.
Species | Disease models |
Experimental records |
Modifiers1 |
Gene coverage2 (%) | |||
---|---|---|---|---|---|---|---|
Positive records | Negative records | Enhancers | Suppressors | Non-modifiers | |||
D. melanogaster |
ADTau |
144 |
571 |
65 |
60 |
549 |
4.89 |
ADAβ |
61 |
6062 |
25 |
22 |
6059 |
44.43 |
|
PD |
1 |
- |
- |
1 |
- |
0.01 |
|
HD |
1260 |
8142 |
130 |
90 |
7732 |
57.82 |
|
SCA1 |
66 |
24 |
16 |
21 |
21 |
0.42 |
|
SCA3 |
623 |
52 |
55 |
520 |
49 |
4.54 |
|
SCA7 |
14 |
19 |
8 |
5 |
18 |
0.23 |
|
PolyQ |
22 |
44 |
7 |
10 |
43 |
0.44 |
|
C. elegans |
ADTau |
75 |
15909 |
- |
75 |
15899 |
97.86 |
ADAβ |
6 |
- |
1 |
5 |
- |
0.04 |
|
HD |
22 |
2 |
1 |
17 |
2 |
0.12 |
|
PD |
290 |
18121 |
- |
268 |
15767 |
98.24 |
|
ALS |
168 |
15909 |
88 |
80 |
15817 |
97.92 |
|
PolyQ |
459 |
40 |
152 |
195 |
20 |
2.11 |
|
S. cerevisiae | ADAβ |
106 |
5262 |
18 |
23 |
5248 |
78.83 |
HD |
82 |
9422 |
28 |
54 |
4670 |
70.83 |
|
PD |
216 |
4699 |
22 |
181 |
4577 |
71.26 |
|
PolyQ | 1 | - | - | 1 | - | 0.01 |
1Certain genes have been identified independently as both an enhancer and suppressor under different experimental conditions.
2With respect to the protein coding genes.