Table 1.

Statistics of genetic modifiers in NeuroGeM

Species	Disease models	Experimental records		Modifiers1			Gene coverage2 (%)
		Positive records	Negative records	Enhancers	Suppressors	Non-modifiers
D. melanogaster	ADTau	144	571	65	60	549	4.89
	ADAβ	61	6062	25	22	6059	44.43
	PD	1	-	-	1	-	0.01
	HD	1260	8142	130	90	7732	57.82
	SCA1	66	24	16	21	21	0.42
	SCA3	623	52	55	520	49	4.54
	SCA7	14	19	8	5	18	0.23
	PolyQ	22	44	7	10	43	0.44
C. elegans	ADTau	75	15909	-	75	15899	97.86
	ADAβ	6	-	1	5	-	0.04
	HD	22	2	1	17	2	0.12
	PD	290	18121	-	268	15767	98.24
	ALS	168	15909	88	80	15817	97.92
	PolyQ	459	40	152	195	20	2.11
S. cerevisiae	ADAβ	106	5262	18	23	5248	78.83
	HD	82	9422	28	54	4670	70.83
	PD	216	4699	22	181	4577	71.26
	PolyQ	1	-	-	1	-	0.01

¹Certain genes have been identified independently as both an enhancer and suppressor under different experimental conditions.

²With respect to the protein coding genes.