Table 4. Responsiveness of ChIMES total and percentage scores between baseline and day 14a.
|
ChIMES total scores |
ChIMES percentage scores |
|||||
|---|---|---|---|---|---|---|
| Mean baseline total score±s.d. | Mean day 14 total score±s.d. | Mean difference (95% CI) P-value | Mean baseline percentage score±s.d. | Mean day 14 percentage score±s.d. | Mean difference (95% CI) P-value | |
|
Parent proxy report | ||||||
| Report D14 mucositis (n=51) |
1.5±3.6 |
13.0±7.5 |
11.4 (−1.0, 22.0)
<0.0001 |
6.4±15.8 |
58.7±32.6 |
51.0 (−4.3, 95.7)
<0.0001 |
| All patients (n=98) |
1.5±3.6 |
8.0±8.5 |
6.6 (−3.0, 22.0)
<0.0001 |
6.4±15.8 |
36.0±37.5 |
29.5 (−13.0, 95.7)
<0.0001 |
|
Child self-report aged 12–18 years | ||||||
| Report D14 mucositis (n=26) |
0.9±2.2 |
10.6±7.2 |
9.8 (1.0, 21.0)
<0.0001 |
3.7±9.5 |
46.5±31.3 |
43.3 (4.3, 91.3)
<0.0001 |
| All patients (n=66) |
0.9±2.2 |
5.1±7.1 |
4.3 (−1.0, 19.0)
<0.0001 |
3.7±9.5 |
22.3±31.0 |
18.9 (−4.3, 82.6)
<0.0001 |
|
Child self-report aged 8 to <12 years | ||||||
| Report D14 mucositis (n=6) |
0.9±1.5 |
12.6±8.9 |
12.3 (0.0, 23.0)
0.063 |
3.7±6.5 |
54.7±38.7 |
53.6 (0.0, 100.0)
0.063 |
| All patients (n=21) | 0.9±1.5 | 5.1±8.1 | 3.7 (−5.0, 23.0) 0.333 | 3.7±6.5 | 22.0±35.4 | 16.1 (−21.7, 100.0) 0.363 |
Abbreviations: ChIMES=Children's International Mucositis Evaluation Scale; CI=confidence interval.
a
Table represents difference between day 14 and baseline with P values from Wilcoxon signed-rank test.