Table 2a. Ovarian tumours: histologial subtypes and frequency of DICER1 mutations.
Tumours studied | Samples with mutation/total cases studied (%) |
---|---|
Sex cord-stromal tumoursa |
9/28 (32) |
Sertoli–Leydig cell tumour | 8/15 (53) |
Juvenile granulosa cell tumour | 0/4 |
Unclassified sex cord-stromal tumour | 1/7 (14) |
Leydig cell tumour | 0/1 |
Sex cord-stromal tumour with annular tubules |
0/1 |
Germ cell tumoursb |
3/99 (3) |
Teratoma—mature | 0/5 |
Teratoma—immature | 0/15 |
Yolk sac tumour | 0/20 |
Embryonal carcinoma | 0/1 |
Mixed malignant germ cell tumour | 2/14 (17) |
Dyserminoma/gonadoblastoma | 1/5 (20) |
Dysgerminoma |
0/39 |
Miscellaneousc |
0/8 |
Embryonal rhabdomyosarcoma | 0/1 |
Small-cell carcinoma of the ovary, hypercalcaemic type |
0/7 |
Total | 12/135 (9) |
Ages 7 months to 66 years (median age 16 years).
Ages birth to 39 years (median age 17 years).
Ages 15 to 46 years (median 18 years).