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. 2013 Nov 19;7:79. doi: 10.3389/fnint.2013.00079

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Copyright © 2013 Typlt, Mirkowski, Azzopardi, Ruth, Pilz and Schmid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term habituation of open field locomotor activity. (A) Changes in average locomotion across days showed no statistically significant difference between genotypes. Error bars indicate standard errors. (B) The long-term habituation scores (median, with whiskers indicating the 5th and 95th percentile) were also not significantly different between the genotypes. Knock-out animals show a slightly higher score (less long-term habituation), which is mainly due to an initial sensitization on day 2, followed by a decline.