. 2013 Mar 27;8(5):1044–1052. doi: 10.1021/cb300729y

Table 1. IC₅₀ Values and Ligand Efficiencies for Compounds A1, A2, B1, C2, D1, and F3 for Selected Protein Kinases.

compound	kinase	IC₅₀ [μM]^a	LE [kcal/mol heavy atom]
A1	CK2	18	0.33
	MAPKAP-K3	21	0.33
	RSK2	196	0.26
	Src	97	0.28
	SRPK1	114	0.28
A2	Aurora A	188	0.26
	CDK2	26	0.33
	CK2	131	0.27
	CLK2	25	0.32
	FGF-R1	252	0.25
	GCK	4	0.38
	IGF-1R	47	0.30
	TAK1	24	0.32
B1	CHK2	17	0.42
	GCK	6	0.46
	HER4	20	0.41
	IGF-1R	25	0.40
	Src	20	0.41
	TAK1	11	0.43
	VEG-FR	39	0.39
	YES1	21	0.41
C2	GSK-3β	25	0.32
C2	SGK1	110	0.28
D1	EPH-B3	158	0.33
D1	FGF-R1	469	0.29
F3	PIM1	22	0.38
F3	PIM3	14	0.40

Hill slopes range from 0.7 to 1.3.

Table 1. IC50 Values and Ligand Efficiencies for Compounds A1, A2, B1, C2, D1, and F3 for Selected Protein Kinases.