Table 1.
Top ten gain/loss spatial functional hotspots (SFHs) of HCC with enriched functions
| Chr | Start pos | End pos | Number of CNVs | Presented gene set | Number gene sets | |
|---|---|---|---|---|---|---|
| Gain |
|
|
|
|
|
|
| 1 |
153.33 |
153.59 |
59 |
bp |
Response to lipopolysaccharide |
4 |
| 1 |
153.27 |
153.43 |
59 |
bp |
Innate immune response |
4 |
| 1 |
153.33 |
153.36 |
59 |
bp |
Response to zinc ion |
2 |
| 1 |
152.27 |
153.43 |
59 |
bp |
Epidermis development |
13 |
| 1 |
152.27 |
153.23 |
59 |
mf |
Structural molecule activity |
8 |
| 1 |
152.88 |
153.43 |
58 |
bp |
Keratinocyte differentiation |
12 |
| 1 |
152.88 |
153.23 |
58 |
bp |
Peptide cross-linking |
6 |
| 1 |
152.88 |
153.23 |
58 |
mf |
Protein binding, bridging |
4 |
| 1 |
153.50 |
153.60 |
57 |
mf |
Protein homodimerization activity |
5 |
| 1 |
153.50 |
153.60 |
57 |
cc |
Perinuclear region of cytoplasm |
5 |
| Loss |
|
|
|
|
|
|
| 8 |
6.84 |
6.88 |
42 |
bp |
Response to virus |
3 |
| 4 |
190.39 |
191.01 |
40 |
mf |
Sequence-specific DNA binding |
6 |
| 4 |
190.39 |
191.01 |
40 |
mf |
Sequence-specific DNA binding transcription Factor activity |
6 |
| 8 |
6.35 |
6.91 |
40 |
cc |
Extracellular space |
7 |
| 4 |
90.80 |
91.76 |
40 |
cc |
Platelet alpha granule lumen |
2 |
| 4 |
90.80 |
91.76 |
40 |
bp |
Platelet degranulation |
2 |
| 8 |
26.61 |
27.47 |
39 |
bp |
Response to stress |
3 |
| 17 |
10.35 |
10.56 |
38 |
bp |
Actin filament-based movement |
2 |
| 8 |
26.37 |
27.31 |
37 |
bp |
Response to cocaine |
2 |
| 8 | 22.88 | 23.08 | 37 | mf | Caspase activator activity | 2 |
Immune-related functions are in italics.