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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Oct 1;5(6):10.1161/CIRCEP.111.969022. doi: 10.1161/CIRCEP.111.969022

Figure 7.

Figure 7

Action potential duration (APD) and activation latency (AL) restitution for rapid pacing, isoproterenol and adenosine in the atrial fibrillation tissue model. (A) Isoproterenol and rapid pacing (S1) increased APD restitution slope >1, while adenosine did not. (B) Isoproterenol and rapid pacing (S1) decreased maximum activation latency, while adenosine increased maximum activation latency (C). Differences in APD restitution slope (top), activation latency magnitude (middle) and activation latency onset (bottom) between the isoproterenol and adenosine AF models (see online supplement for details, note that differences are the inverse of the contribution of each ionic current modification shown in panels A and B).