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. 2013 Jun 19;305(4):R397–R403. doi: 10.1152/ajpregu.00216.2013

Fig. 1.

Fig. 1.

A: in response to the reduced uterine perfusion pressure (RUPP) procedure on gestational day 14, mean arterial pressure (MAP) on gestational day 19 was increased compared with normal pregnant (NP) control animals (100 ± 1.6 vs. 132 ± 2.7 mmHg). Sildenafil administration alone had no net effect on MAP, but significantly attenuated RUPP-induced hypertension (115 ± 1 mmHg). B: RUPP procedure had no significant effect on placental mass, but sildenafil caused a slight, but significant, increase in placental mass on gestational day 19. C: fetal weights were significantly decreased in response to the RUPP procedure (2.22 ± 0.06 vs. 1.92 ± 0.09). Sildenafil administration had no effect on either control or RUPP animals. n = 10–12 for each experimental group. Statistically significant (P < 0.05) comparisons are indicated by brackets.