Fig. 4.

Blockade of CCK1 receptors with devazepide converts animals unresponsive to EA into responders. A: after CCK blockade in the rVLM, nonresponders were converted to responders during a second 30-min EA treatment. Letters a–c displayed in the bars of the histogram correspond with blood pressures a to c shown above. Arrows indicate time of gastric distension application. B: in the absence of second EA, devazepide did not affect the primary gastric distension reflex. C: vehicle into the rVLM did not modify the nonresponsiveness to EA. *Significant difference, P < 0.05 compared with control before EA. #Significant difference, P < 0.05 compared with CCK blockade without the second EA. ^Significant difference, P < 0.05 compared with vehicle group.