Table 2.
Characteristics of the animal models.
| NC group (n = 6) | HF group (n = 6) | MET group (n = 6) | |
|---|---|---|---|
| Weight at baseline (g) | 218.75 ± 16.27 | 219.60 ± 13.78 | 219.60 ± 13.78 |
| Weight at the end (g) | 458.50 ± 51.50 | 573.30 ± 44.57* | 524.2 ± 17.2* |
| FPG (mmol/L) | 5.40 ± 0.27 | 6.02 ± 0.29* | 5.65 ± 0.42 |
| Fins (mIU/L) | 10.98 ± 7.20 | 33.07 ± 12.67* | 12.35 ± 7.90# |
| TC (mmol/L) | 1.26 ± 0.19 | 1.48 ± 0.15 | 1.47 ± 0.22 |
| TG (mmol/L) | 0.57 ± 0.16 | 0.67 ± 0.24 | 0.31 ± 0.07∗# |
| LDL-c (mmol/L) | 0.35 ± 0.10 | 0.48 ± 0.11* | 0.52 ± 0.08* |
| HDL-c (mmol/L) | 1.11 ± 0.20 | 0.97 ± 0.17 | 1.05 ± 0.12 |
| GIR (μmol·kg−1·min−1) | 8.63 ± 0.96 | 3.65 ± 0.68* | 7.99 ± 0.92# |
| PEDF (μg/mL) | 1.77 ± 0.14 | 2.16 ± 0.09* | 1.69 ± 0.24# |
Data are presented as mean ± SD and analyzed by one-way ANOVA with the Games Howell test for post hoc analysis. FPG: fasting plasma glucose; Fins: fasting serum insulin; TC: total cholesterol; TG: triglycerides; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; PEDF: pigment epithelium-derived factor; GIR: glucose infusion rate; NC: normal control; HF: high fat; MET: metformin. *P < 0.05, compared with NC group; # P < 0.05, compared with HF group.