Table 1.
Selected characteristics of the proband cervical and vulvar cancer cases, non-proband cervical and vulvar cancer cases, and population controls, Seattle-Puget Sound Region, 1986–2004
| Cervical squamous cell carcinoma
|
Cervical adenocarcinoma
|
Vulvar squamous cell carcinoma
|
Population controls
|
|||||
|---|---|---|---|---|---|---|---|---|
| Proband cases (n=43) | Non-proband cases (n=356) | Proband cases (n=96) | Non-proband cases (n=406) | Proband cases (n=53) | Non-proband cases (n=473) | Cervical cancer1 (n=861) | Vulvar cancer (n=1,111) | |
| Characteristic | ||||||||
| Tumor behavior, N (%) | ||||||||
| In situ | - | - | 79 (82.3) | 241 (59.4) | 49 (92.5) | 402 (85.0) | - | - |
| Invasive | 43 (100) | 356 (100) | 17 (17.7) | 165 (40.6) | 4 (7.5) | 71 (15.0) | - | - |
| HPV DNA, N (%) | ||||||||
| Not tested | 29 (67.4) | 105 (29.5) | 54 (56.2) | 102 (25.1) | 20 (37.7) | 106 (22.4) | - | - |
| Negative | 3 (7.0) | 19 (5.3) | 3 (3.1) | 42 (10.3) | 3 (5.7) | 39 (8.3) | - | - |
| HPV 16+/18− | 11 (25.6) | 164 (46.1) | 24 (25.0) | 118 (29.0) | 23 (43.4) | 271 (57.3) | - | - |
| HPV 16−/18+ | 0 | 21 (5.9) | 10 (10.4) | 101 (24.9) | 2 (3.8) | 20 (4.2) | ||
| HPV 16+/18+ | 0 | 21 (5.9) | 5 (5.2) | 28 (6.9) | 1 (1.9) | 10 (2.1) | ||
| Other type (s) | 0 | 26 (7.3) | 0.0 | 15(3.7) | 4 (7.6) | 27 (5.7) | - | - |
| Mean age (years) | 38.0 | 43.1 | 32.8 | 39.7 | 39.3 | 48.3 | 42.6 | 45.8 |
| Cigarette smoking, N (%) | ||||||||
| Never | 24 (55.8) | 126 (35.4) | 56 (58.3) | 210 (51.7) | 15 (28.3) | 92 (19.5) | 468 (54.4) | 577 (51.9) |
| Former | 9 (20.9) | 100 (28.1) | 21 (21.9) | 109 (26.9) | 6 (11.32) | 111 (23.4) | 223 (25.9) | (303) 27.3 |
| Current | 10 (23.3) | 130 (36.5) | 19 (19.8) | 87 (21.4) | 32 (60.38) | 270 (57.1) | 170 (19.7) | 231 (20.8) |
| Number of lifetime sexual partners, N (%) | ||||||||
| 1 | 3 (7.0) | 34 (9.6) | 6 (6.3) | 52 (12.8) | 1 (1.9) | 42 (8.9) | 204 (23.7) | 295 (26.5) |
| 2 to 4 | 13 (30.2) | 109 (30.6) | 18 (18.8) | 116 (28.6) | 6 (11.3) | 105 (22.2) | 258 (30.0) | 344 (30.9) |
| 5 to 14 | 22 (51.2) | 150 (42.1) | 46 (47.9) | 171 (42.1) | 29 (54.7) | 204 (43.1) | 291 (33.8) | 344 (30.9) |
| ≥ 15 | 5 (11.6) | 63 (17.7) | 26 (27.1) | 67 (16.5) | 17 (32.1) | 121 (25.6) | 108 (12.5) | 126 (11.3) |
| Number of births, N (%) | ||||||||
| 0 | 11 (25.6) | 66 (18.5) | 43 (44.8) | 126 (31.3) | 19 (35.9) | 132 (27.9) | 224 (26.0) | 248 (22.3) |
| 1 | 8 (18.6) | 58 (16.25) | 14 (14.6) | 72 (17.9) | 11 (20.8) | 90 (19.0) | 135 (15.7) | 154 (13.9) |
| 2 | 10 (23.3) | 108 (30.25) | 30 (31.3) | 121 (30.0) | 18 (34.0) | 117 (24.7) | 255 (29.6) | 338 (30.4) |
| ≥ 3 | 14 (32.5) | 124 (34.8) | 9 (9.4) | 84 (20.8) | 5 (9.4) | 134 (28.3) | 247 (28.7) | 371 (33.4) |
1
Excluding women with prior hysterectomy