Table 3.
IL10, IL12A, IL12B, IL10RA, IL10RB, IL12RB1, and IL12RB2 tagSNP associations with cervical and vulvar cancer, Seattle-Puget Sound region, 1986–2004
| Gene | SNP | Cervical squamous cell carcinoma
|
Cervical adenocarcinoma
|
Vulvar squamous cell carcinoma
|
MAF in population controls | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16 triads, 27 dyads, 357 unrelated cases, and 861 population controls
|
55 triads, 41 dyads, 406 unrelated cases, and 861 population controls
|
17 triads, 36 dyads, 474 unrelated cases, and 1,111 population controls
|
||||||||||||
| MAF1 (cases) | Odds ratio | 95% CI | Holm-adjusted p-value | MAF (cases) | Odds ratio | 95% CI | Holm-adjusted p-value | MAF (cases) | Odds ratio | 95% CI | Holm-adjusted p-value | |||
| IL10 | rs3024505 | 0.14 | 0.70 | (0.37,1.36) | 0.14 | 1.21 | (0.8,1.82) | 0.16 | 0.57 | (0.27,1.17) | 0.15 | |||
| rs3024498 | 0.26 | 1.31 | (0.82,2.08) | 0.26 | 0.90 | (0.63,1.27) | 0.25 | 0.89 | (0.54,1.45) | 0.27 | ||||
| rs3024509 | 0.07 | 1.09 | (0.48,2.48) | 0.07 | 0.78 | (0.4,1.52) | 0.06 | 1.64 | (0.84,3.19) | 0.07 | ||||
| rs3021094 | 0.07 | 0.45 | (0.15,1.35) | 0.08 | 1.11 | (0.64,1.9) | 0.08 | 1.28 | (0.66,2.48) | 0.08 | ||||
| rs1800871 | 0.23 | 1.11 | (0.65,1.89) | 0.24 | 1.10 | (0.79,1.53) | 0.25 | 1.62 | (1.04,2.54) | 0.060 | 0.23 | |||
| rs1800894 | 0.04 | 0.86 | (0.27,2.79) | 0.03 | 0.51 | (0.17,1.58) | 0.03 | 1.16 | (0.42,3.25) | 0.04 | ||||
| rs1800896 | 0.46 | 1.22 | (0.79,1.89) | 0.48 | 1.00 | (0.75,1.33) | 0.46 | 0.91 | (0.58,1.43) | 0.50 | ||||
| rs1800890 | 0.38 | 1.26 | (0.81,1.96) | 0.36 | 1.10 | (0.82,1.47) | 0.37 | 0.78 | (0.53,1.15) | 0.39 | ||||
| IL10RA | rs4252301 | 0.09 | 0.57 | (0.03,9.55) | 0.11 | 1.05 | (0.25,4.34) | 0.11 | NE | 0.11 | ||||
| rs4252253 | 0.33 | 0.38 | (0.16,0.91) | 0.100 | 0.31 | 1.13 | (0.74,1.71) | 0.38 | 1.02 | (0.58,1.79) | 0.33 | |||
| rs2256111 | 0.16 | 0.67 | (0.4,1.12) | 0.15 | 1.21 | (0.88,1.68) | 0.19 | 0.95 | (0.61,1.48) | 0.17 | ||||
| rs3135932 | 0.10 | 1.11 | (0.56,2.17) | 0.11 | 1.21 | (0.8,1.83) | 0.11 | 0.79 | (0.41,1.51) | 0.11 | ||||
| rs4252279 | 0.04 | 0.64 | (0.25,1.61) | 0.04 | 1.02 | (0.61,1.7) | 0.04 | 0.95 | (0.45,1.99) | 0.03 | ||||
| rs4252314 | 0.02 | 1.57 | (0.63,3.93) | 0.03 | 2.23 | (1.26,3.96) | 0.002 | 0.02 | 1.11 | (0.33,3.72) | 0.03 | |||
| rs4252286 | 0.31 | 0.52 | (0.1,2.74) | 0.31 | 0.71 | (0.24,2.08) | 0.36 | 0.28 | (0.03,2.59) | 0.32 | ||||
| rs2229113 | 0.05 | 1.01 | (0.62,1.67) | 0.05 | 1.16 | (0.84,1.6) | 0.05 | 0.95 | (0.58,1.56) | 0.05 | ||||
| rs2229114 | 0.46 | 0.48 | (0.11,2.07) | 0.46 | 1.03 | (0.48,2.22) | 0.41 | 1.92 | (0.88,4.15) | 0.45 | ||||
| rs9610 | 0.33 | 1.76 | (1.15,2.68) | 0.001 | 0.31 | 0.75 | (0.53,1.06) | 0.37 | 1.16 | (0.72,1.87) | 0.32 | |||
| IL10RB | rs999788 | 0.30 | 0.90 | (0.5,1.61) | 0.29 | 0.94 | (0.63,1.41) | 0.28 | 0.72 | (0.39,1.31) | 0.28 | |||
| rs2239573 | 0.25 | 1.12 | (0.68,1.83) | 0.26 | 1.07 | (0.78,1.47) | 0.25 | 1.13 | (0.71,1.81) | 0.26 | ||||
| rs2834167 | 0.20 | 0.97 | (0.54,1.75) | 0.22 | 0.97 | (0.68,1.39) | 0.21 | 0.70 | (0.42,1.18) | 0.22 | ||||
| rs2284552 | 0.44 | 0.85 | (0.45,1.61) | 0.43 | 0.96 | (0.66,1.41) | 0.46 | 0.75 | (0.42,1.34) | 0.45 | ||||
| rs2849997 | 0.11 | 1.02 | (0.61,1.72) | 0.12 | 0.98 | (0.7,1.37) | 0.12 | 0.94 | (0.64,1.39) | 0.12 | ||||
| rs8178474 | 0.30 | 0.73 | (0.34,1.6) | 0.30 | 0.98 | (0.61,1.58) | 0.30 | 0.64 | (0.32,1.3) | 0.32 | ||||
| rs2834168 | 0.47 | 0.70 | (0.43,1.15) | 0.42 | 0.98 | (0.71,1.34) | 0.45 | 1.05 | (0.7,1.58) | 0.45 | ||||
| rs2247526 | 0.47 | 1.24 | (0.76,2.01) | 0.43 | 0.87 | (0.63,1.2) | 0.46 | 1.27 | (0.85,1.89) | 0.45 | ||||
| rs2248118 | 0.30 | 1.09 | (0.69,1.71) | 0.33 | 0.93 | (0.66,1.31) | 0.31 | 1.16 | (0.8,1.67) | 0.33 | ||||
| rs2843944 | 0.50 | 0.50 | (0.28,0.91) | 0.120 | 0.48 | 0.97 | (0.7,1.34) | 0.46 | 0.97 | (0.62,1.52) | 0.47 | |||
| rs999259 | 0.05 | 1.32 | (0.91,1.92) | 0.05 | 0.86 | (0.64,1.15) | 0.06 | 1.23 | (0.82,1.83) | 0.06 | ||||
| rs8178556 | 0.38 | 0.83 | (0.28,2.42) | 0.38 | 1.23 | (0.69,2.19) | 0.39 | 0.85 | (0.28,2.59) | 0.39 | ||||
| rs1058867 | 0.19 | 0.89 | (0.53,1.47) | 0.19 | 1.06 | (0.77,1.46) | 0.19 | 1.15 | (0.74,1.77) | 0.20 | ||||
| rs7281762 | 0.20 | 0.73 | (0.38,1.41) | 0.19 | 1.11 | (0.76,1.61) | 0.19 | 0.74 | (0.44,1.25) | 0.19 | ||||
| IL12A | rs582537 | 0.42 | 0.64 | (0.38,1.08) | 0.44 | 0.97 | (0.72,1.31) | 0.46 | 0.98 | (0.65,1.47) | 0.45 | |||
| rs2243135 | 0.40 | 1.17 | (0.72,1.91) | 0.38 | 0.94 | (0.69,1.29) | 0.39 | 0.86 | (0.55,1.35) | 0.40 | ||||
| rs2243154 | 0.09 | 1.03 | (0.41,2.61) | 0.10 | 0.70 | (0.39,1.26) | 0.09 | 1.19 | (0.67,2.1) | 0.09 | ||||
| IL12B | rs6870828 | 0.49 | 1.53 | (0.86,2.73) | 0.49 | 1.05 | (0.75,1.49) | 0.48 | 0.91 | (0.6,1.4) | 0.48 | |||
| rs3181225 | 0.20 | 1.85 | (1.07,3.21) | 0.080 | 0.20 | 1.14 | (0.76,1.71) | 0.21 | 1.16 | (0.69,1.96) | 0.17 | |||
| rs3181224 | 0.11 | 1.16 | (0.58,2.32) | 0.11 | 1.08 | (0.63,1.85) | 0.09 | 0.30 | (0.12,0.74) | 0.001 | 0.11 | |||
| rs1368439 | 0.17 | 0.84 | (0.41,1.68) | 0.19 | 0.96 | (0.64,1.43) | 0.18 | 0.92 | (0.55,1.54) | 0.19 | ||||
| rs3212227 | 0.21 | 0.50 | (0.23,1.09) | 0.18 | 0.87 | (0.59,1.29) | 0.20 | 0.98 | (0.61,1.58) | 0.20 | ||||
| rs3213119 | 0.03 | 0.52 | (0.11,2.48) | 0.03 | 0.66 | (0.2,2.13) | 0.02 | 0.50 | (0.14,1.84) | 0.03 | ||||
| rs2853694 | 0.49 | 0.80 | (0.49,1.33) | 0.49 | 1.03 | (0.75,1.42) | 0.49 | 1.23 | (0.81,1.85) | 0.48 | ||||
| rs2569253 | 0.46 | 0.64 | (0.39,1.04) | 0.46 | 0.93 | (0.68,1.28) | 0.44 | 0.69 | (0.45,1.07) | 0.47 | ||||
| rs3181216 | 0.31 | 0.90 | (0.52,1.53) | 0.31 | 1.00 | (0.72,1.4) | 0.33 | 1.22 | (0.8,1.86) | 0.33 | ||||
| rs1433048 | 0.17 | 0.88 | (0.45,1.73) | 0.22 | 0.85 | (0.58,1.26) | 0.18 | 1.12 | (0.67,1.88) | 0.18 | ||||
| rs2546893 | 0.50 | 1.23 | (0.78,1.93) | 0.49 | 1.12 | (0.82,1.52) | 0.48 | 1.09 | (0.73,1.63) | 0.50 | ||||
| rs730691 | 0.36 | 0.57 | (0.32,1.01) | 0.450 | 0.36 | 0.86 | (0.62,1.2) | 0.36 | 0.98 | (0.66,1.44) | 0.37 | |||
| rs2546890 | 0.48 | 1.16 | (0.75,1.79) | 0.47 | 0.99 | (0.74,1.32) | 0.47 | 0.89 | (0.58,1.36) | 0.48 | ||||
| rs10052709 | 0.14 | 1.11 | (0.61,2.03) | 0.14 | 0.96 | (0.59,1.57) | 0.10 | 0.67 | (0.34,1.32) | 0.13 | ||||
| rs10045431 | 0.28 | 0.90 | (0.53,1.51) | 0.30 | 1.02 | (0.73,1.43) | 0.26 | 0.65 | (0.41,1.03) | 0.29 | ||||
| IL12RB1 | rs445521 | 0.40 | 1.08 | (0.65,1.79) | 0.40 | 1.00 | (0.74,1.34) | 0.39 | 0.98 | (0.65,1.49) | 0.42 | |||
| rs17885963 | 0.06 | 2.00 | (1.03,3.91) | 0.320 | 0.05 | 0.70 | (0.34,1.48) | 0.05 | 1.07 | (0.45,2.53) | 0.05 | |||
| rs3746190 | 0.40 | 1.65 | (0.97,2.8) | 0.37 | 1.04 | (0.77,1.43) | 0.37 | 0.70 | (0.49,1.01) | 0.150 | 0.39 | |||
| rs383483 | 0.50 | 0.78 | (0.47,1.3) | 0.50 | 0.75 | (0.55,1.01) | 0.150 | 0.49 | 1.31 | (0.88,1.94) | 0.48 | |||
| rs438421 | 0.30 | 0.77 | (0.48,1.24) | 0.28 | 0.82 | (0.57,1.17) | 0.28 | 1.03 | (0.63,1.68) | 0.28 | ||||
| rs2045386 | 0.40 | 1.13 | (0.73,1.74) | 0.42 | 0.79 | (0.58,1.09) | 0.40 | 0.84 | (0.57,1.25) | 0.42 | ||||
| rs11575934 | 0.32 | 0.94 | (0.56,1.6) | 0.32 | 1.51 | (1.12,2.05) | 0.001 | 0.33 | 1.16 | (0.79,1.71) | 0.32 | |||
| rs11575926 | 0.18 | 0.97 | (0.51,1.85) | 0.16 | 1.39 | (0.97,2.00) | 0.18 | 0.79 | (0.48,1.32) | 0.17 | ||||
| rs11673460 | 0.07 | 1.59 | (0.7,3.62) | 0.05 | 0.72 | (0.36,1.42) | 0.06 | 0.64 | (0.28,1.46) | 0.06 | ||||
| rs11086087 | 0.09 | 0.54 | (0.2,1.45) | 0.13 | 1.49 | (0.96,2.3) | 0.13 | 1.44 | (0.83,2.52) | 0.12 | ||||
| IL12RB2 | rs3762315 | 0.18 | 0.70 | (0.38,1.27) | 0.22 | 0.70 | (0.46,1.07) | 0.18 | 1.18 | (0.75,1.85) | 0.20 | |||
| rs3762317 | 0.13 | 0.71 | (0.33,1.52) | 0.17 | 0.70 | (0.42,1.15) | 0.13 | 1.18 | (0.67,2.09) | 0.15 | ||||
| rs12142823 | 0.14 | 0.61 | (0.27,1.34) | 0.18 | 0.76 | (0.46,1.27) | 0.14 | 1.19 | (0.67,2.13) | 0.16 | ||||
| rs7544381 | 0.33 | 0.70 | (0.41,1.18) | 0.36 | 0.92 | (0.66,1.28) | 0.34 | 1.08 | (0.7,1.67) | 0.36 | ||||
| rs17129741 | 0.04 | 0.71 | (0.20,2.59) | 0.03 | 0.66 | (0.26,1.63) | 0.04 | 1.16 | (0.45,3) | 0.04 | ||||
| rs12138219 | 0.18 | 0.64 | (0.33,1.25) | 0.21 | 0.70 | (0.45,1.1) | 0.19 | 1.31 | (0.77,2.22) | 0.20 | ||||
| rs17129794 | 0.16 | 0.59 | (0.29,1.2) | 0.18 | 1.03 | (0.7,1.52) | 0.19 | 0.88 | (0.5,1.55) | 0.17 | ||||
| rs1495963 | 0.02 | 0.73 | (0.13,4.14) | 0.02 | 1.42 | (0.51,3.93) | 0.02 | 1.56 | (0.48,5.04) | 0.01 | ||||
| rs12145984 | 0.14 | 0.47 | (0.16,1.39) | 0.17 | 1.02 | (0.66,1.58) | 0.15 | 0.70 | (0.39,1.24) | 0.17 | ||||
| rs3790565 | 0.18 | 0.49 | (0.25,0.95) | 0.210 | 0.18 | 0.89 | (0.6,1.31) | 0.18 | 0.86 | (0.48,1.55) | 0.18 | |||
| rs10749775 | 0.12 | 0.53 | (0.22,1.27) | 0.13 | 1.00 | (0.64,1.55) | 0.13 | 0.90 | (0.44,1.85) | 0.12 | ||||
| rs3790567 | 0.23 | 0.58 | (0.32,1.03) | 0.600 | 0.23 | 0.86 | (0.6,1.22) | 0.24 | 0.91 | (0.56,1.48) | 0.24 | |||
| rs2307153 | 0.02 | 0.86 | (0.17,4.44) | 0.02 | 1.18 | (0.48,2.89) | 0.03 | 1.60 | (0.44,5.77) | 0.02 | ||||
| rs17129908 | 0.12 | 0.66 | (0.32,1.38) | 0.10 | 0.79 | (0.48,1.33) | 0.12 | 0.86 | (0.47,1.59) | 0.12 | ||||
| rs4297265 | 0.40 | 0.46 | (0.26,0.82) | 0.002 | 0.42 | 1.01 | (0.74,1.37) | 0.42 | 0.84 | (0.57,1.23) | 0.43 | |||
| rs2229546 | 0.33 | 0.43 | (0.21,0.87) | 0.030 | 0.35 | 1.12 | (0.8,1.57) | 0.33 | 0.86 | (0.57,1.31) | 0.34 | |||
1
MAF: Minor allele frequency