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. Author manuscript; available in PMC: 2014 Oct 10.
Published in final edited form as: Neuroscience. 2013 Jul 11;250:10.1016/j.neuroscience.2013.06.068. doi: 10.1016/j.neuroscience.2013.06.068

Figure 3. Representative phrenic neurograms depicting experimental protocols in rats intrathecally treated with PKA inhibitor and PKA activator.

Figure 3

A, intrathecal PKA inhibitor (KT5720) injected prior to AIH; B, KT5720 alone C, PKA activator (8-br-cAMP) prior to AIH and D, 8-br-cAMP alone treated for equivalent experimental duration respectively. Intrathecal PKA inhibition greatly enhances pLTF (A). PKA activation blunts expression of pLTF (C). Neither PKA activation nor inhibition augments phrenic motor activity (B&D).