Figure 6. Phrenic and hypoglossal (XII) responses during hypoxic episodes (i.e. short-term hypoxic response).
Changes in integrated phrenic and XII burst amplitudes during final minute of hypoxic exposures (average of 3) from intrathecal vehicle, 5-HT7 antagonist, PKA inhibitor and PKA activator. Phrenic and hypoglossal bursts amplitudes significantly increased above baseline in all rats exposed to AIH (data not shown). No significant differences were observed between treatment groups in phrenic (solid) or hypoglossal (open) burst amplitudes from rats receiving intrathecal SB269970, KT5720, vehicle or 8-Br-cAMP prior to AIH. Values are means±S.E.M.